Effects of oral administration of BHC on the blood enzymes of rabbits.

The effects on the blood enzymes of rabbits were ascertained by daily oral administration of 25 mg BHC per kg body weight for twelve weeks. The amount of BHC in the blood increased progressively and reached a maximum of 86.0 12 pg per ml. The levels of enzymes were elevated though there was a nonsignificant increase in the pH value of the blood of the treated group. An increase of 0323 and 0.587 units of acid and alkaline phosphatases, respectively, was observed for every one microgram per accumulation of BHC in the blood. The analysis of blood for enzymes AST and ALT, indicated that one microgram of blood BHC increased the two enzymes by 0.344 and 0.697 units. The treated group of rabbits showed many behavioural abnormalities. (JPMA 37: 220 , 1987).